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This dual benefit positions semaglutide as a powerful tool, appealing both to healthcare providers aiming for comprehensive metabolic improvements and to patients seeking effective diabetes management solutions combined with weight loss benefits

Patients who were highly insulin resistant often show substantial improvement

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Nat Reviews Drug Discovery 2025

The increased sympathetic tone may explain a known GLP-1RA class effect of a modest but significant increase in heart rate, the clinical consequences of which are undetermined